Wyrtzen spoke in many churches and venues, holding meetings from the streets to stadiums; he is credited with influencing Billy Graham, George Verwer and other evangelistic leaders.

In 1933, he helped to form XBA, Chi Beta Alpha (Christians Born Again), a Bible study and fellowship group for young men; Phi Gamma was organized for women.

[5] Strongly influenced by another youth evangelist, Percy Crawford,[6] Wyrtzen took to the air over WBBC as a preacher and then began the Word of Life broadcast over WHN in 1941.

[7] From the 1950s–1980s, Wyrtzen's daily Word of Life radio broadcast was heard nationwide, featuring Christian music, testimonies by young people, and his sermons, many recorded at the Schroon Lake camp.

[9] The Word of Life ministry developed conference centers at Schroon Lake and, in the 1980s, in Hudson, Florida.

Wyrtzen spoke in many churches and venues, holding meetings from the streets to stadiums; he is credited with influencing Billy Graham, George Verwer and other evangelistic leaders.