The film stars original Jackass members Knoxville, Steve-O, Dave England, Wee Man, Danger Ehren, Chris Pontius, Preston Lacy, as well as newcomers Sean "Poopies" McInerney, Zach Holmes, Jasper Dolphin, Eric Manaka, Rachel Wolfson, the Jackass film crew, and celebrity guests.

This is the first Jackass film not to feature Ryan Dunn following his death in 2011 and the first without Bam Margera being a primary cast member as he was fired during production, appearing in only one skit.

Stunts and pranks with the main cast include Knoxville facing a bull resulting in dangerous consequences; Dave England unsuspectingly getting pig semen dumped on him during a fake interview about the movie; Steve-O having his penis used as a beehive; Ehren McGhehey being subjected to painful tests with an athletic cup; Pontius' penis being used as the paddle for paddle ball; a vulture eating pieces of meat off Wee Man's body; and Preston Lacy's testicles being used as a miniature punching bag.

The newcomers are also featured in many of the stunts and pranks, including Poopies trying to kiss a Texas rat snake; Jasper Dolphin being shot off a ramp by large industrial fans while he's holding a parachute; Zach Holmes gliding down into a bed of cactuses; Eric Manaka riding a bicycle full speed into a false wall; and Rachel Wolfson having a scorpion sting her lips.

The final stunt, the Vomitron, features Zach, Dave, Eric, Poopies, Steve-O and Jasper drinking milk while strapped to a high-speed carousel.

As they start vomiting, Knoxville and the rest of the cast initiate an attack involving paintball guns, a tennis machine and multiple explosions.

The cast from the previous films return, with the exception of original Jackass member Ryan Dunn, who died in 2011,[9] but does appear through archival footage in the end credits and the movie is seen as a tribute to him.

Cameos in the intro sequence include Arthur H. Spiegel III, Errol Chatham, Alia Shawkat, Jalen Ramsey, Otmara Marrero, DJ Paul, Sean Malto, Mike Carroll, Breana Geering, Rick Howard, Compston "Dark Shark" Wilson, Tyler, the Creator, Lionel Boyce, Travis "Taco" Bennett, Louie Anderson, Syd tha Kyd, Vincent Alvarez, and Tony Hawk.

In July 2019, former cast member Chris Raab said that he had interviewed the Jackass crew on his Bathroom Break podcast and noted that everyone was still open to a fourth film should Knoxville, Jeff Tremaine, and Spike Jonze agree.

"[17] During his July 12, 2021 appearance on Jimmy Kimmel Live!, Knoxville revealed the film's title and showed the first official photos.

[18] In January 2021, Bam Margera claimed that Paramount Pictures regarded him as a liability, owing to his behavior leading up to and during production.

[19] On February 11, Margera posted several videos to his Instagram account, in which he admitted to breaking his sobriety and claimed that he had been officially fired from the filming of Jackass 4.

Margera alleged that Paramount had been forcing him to take antidepressants, submit to random urine tests, and to check in to two rehabilitation facilities using his own money.

[22] On August 9, 2021, Margera officially filed a lawsuit against Knoxville, Jonze, and Tremaine, as well as against Paramount Pictures, MTV, Dickhouse Entertainment, and Gorilla Flicks, alleging that he was wrongfully fired from the film's production.

[25] On May 25, Knoxville confirmed six new cast members: Jasper Dolphin of Odd Future, and one of the stars of Loiter Squad; Jasper's ex-convict father Compston "Dark Shark" Wilson, who made recurring guest appearances throughout the film; Eric Manaka, who had a role in Knoxville's film Action Point; stand-up comedian Rachel Wolfson;[26] Zach Holmes from Too Stupid to Die; and surfer Sean "Poopies" McInerney[27] who had previously appeared in the Jackass Shark Week special.

[38] Filming was halted in March 2020 due to the COVID-19 pandemic and resumed seven months later on October 19, 2020,[39] with Dimitry Elyashkevich serving as cinematographer.

[55] It is the third film from Paramount to finish first at the box office in its opening weekend during the COVID-19 pandemic, following A Quiet Place Part II and Scream.

Social media monitor RelishMix credited the film's box office performance to a large online fanbase, positive word of mouth, and shoutouts to Margera, Knoxville's physical journey, and "memories of Jackass over 22 years".

Box office analytics firm EntTelligence also noted the film's runtime of 96 minutes for increasing the number of showtimes in theaters.

The website's consensus reads: "A gleefully gonzo franchise revival, Jackass Forever will make you worry more than ever for the cast's health and safety – but not enough to hold back the laughter.

[56] Owen Gleiberman of Variety wrote: "the team have not slacked off in their mission to create what are basically the world's most stupidly elaborate frat-house hazing stunts, and to stage them with a juvenile masochistic fervor that lies somewhere between psychotic and religious".

[72] David Fear of Rolling Stone gave it four out of five and wrote: "Forget the title: Jackass can't go on forever.

[7] The most notable added bits include: Johnny Knoxville, disguised as Irving Zisman, ringing the fire alarm of a retirement home in front of his unsuspecting caretaker; Steve-O having his eyebrows waxed off by a raptor and letting another raptor eat fish out of his anus; Dave England throwing a brick tied to his penis from a scaffold; Wee Man unsuspectingly getting horse semen dumped on him in a similar fashion to what happened to Dave England; Preston Lacy getting shot in the stomach by a tennis ball from an elephant gun; Ehren McGhehey having a bowling ball thrown against his nuts by a professional bowler as part of the "Cup Tests"; Sean "Poopies" McInerney standing on a stepladder and hitting it with a sledgehammer saying he'll show him; Jasper Dolphin getting hit on the head by a boxing glove attached to an arrow from a bow; Zach Holmes unsuspectingly getting shot with paint and glitters from an air pressure cannon while wearing a VR headset; and Rachel Wolfson, Chris Pontius, and Steve-O eating sashimi off Zach's sweaty body.