[10][11] Her breakthrough role came in 2003 when she starred in the Ghanaian film "Princess Tyra," which brought her widespread recognition and cemented her status as a leading actress in West African cinema.
[12] Following the success of "Princess Tyra," Appiah went on to appear in numerous other Ghanaian and Nigerian films, further establishing herself as one of the most prominent and influential actresses in the region[13] Alongside her acting work, Appiah has also been involved in various philanthropic initiatives, using her celebrity to support causes such as education and healthcare in Ghana.
[15] Appiah's appearance on screen became regular when she was invited by Edward Seddoh Junior, the writer of Things We Do For Love, where she played the role of Enyonam Blagogee.
Appiah remembers herself as being very shy the first time she went on set: "It was a Venus Film Production titled Divine Love and I had to play the role of Kate, the protagonist.
Jackie Appiah is widely regarded as one of the most successful and influential actresses to emerge from the Ghanaian and Nigerian film industries, with a career spanning over two decades.
[16] Appiah was already known to Nollywood through her many successful Ghanaian films including Beyoncé - The President Daughter, Princess Tyra, Passion of the Soul, Pretty Queen, The Prince's Bride, The King is Mine and The Perfect Picture.
[21] Appiah's face can be seen on many billboards and TV commercials in Ghana including a GSMF advert on protection against HIV/AIDS.