[15] In 2022, she was nominated by the People's Democratic Party gubernatorial candidate, Abdul-Azeez Olajide Adediran, as the running mate for the 2023 Lagos state governorship election.

[25][26] In 2010, she starred in gangsters two-parter film Omo Ghetto that became a cult-classic with massive influence on Yoruba pop-culture at the time.

[13] Akindele played the lead character in the TV show Jenifa's Diary, alongside Fisayo Ajisola, Falz, Juliana Olayode, and Aderounmu Adejumoke.

[31] Justifying her nomination, Abdul-Azeez Olajide Adediran monikered "Jandor", noted that the actress added more value to his candidacy in the 2023 general elections.

[33][34] Akindele established a non-governmental organization known as the Jenifa Foundation, which aims at providing young people with vocational skills.

[39] In November 2019, she signed an endorsement deal with WAW Nigeria, a company that manufactures washing detergent and bar soap.

JJC Skillz announced the end of the union between him and the popular actress which lasted six years via his official Instagram handle on June 30, 2022.

[49] She later appeared in a Nigeria Centre for Disease Control video to raise awareness about the virus[50] The actress and her husband were sentenced to a 14-day community service after pleading guilty to violating the lockdown order.

She is the producer and director of the four highest grossing Nollywood movies of all time; Everybody Loves Jenifa, A Tribe Called Judah,[53] Battle on Buka Street and Omo Ghetto: The Saga.