Jacqueline Ruth Cain (May 22, 1928 – September 15, 2014) was an American jazz singer known for her partnership with her husband in the duo Jackie and Roy.

Born in Milwaukee, Wisconsin, Cain was the daughter of an office furniture salesman who also managed a community theater.

[2] In 1947, at the age of 19, she was introduced to Roy Kral by Bob Anderson, a fellow member of the Burkhart band.

[1] Cain died at her home in Montclair, New Jersey, aged 86, on September 15, 2014, from complications of a stroke she suffered in 2010.

[3] Douglas Martin of The New York Times called Jackie and Roy "the most famous vocal duo in jazz history".