[3] After graduating from high school, Greene moved to Sacramento, where he began playing at local establishments, including Marilyn's, Fox & Goose,[5] and The Blue Lamp.

King, Phil Lesh, Ratdog, Huey Lewis, Susan Tedeschi, Taj Mahal, and Buddy Guy, and has played major U.S. festivals, including All Good, Gathering of the Vibes, Mountain Jam, Grateful Garcia Gathering, Newport Jazz, Newport Folk, South by Southwest, Wakarusa, Winnipeg Folk, Bonnaroo, Outside Lands, and Rothbury.

Meanwhile, Greene continued to pursue solo efforts, releasing Giving Up the Ghost on 429 Records in April 2008, and made his second visit to Late Night with Conan O'Brien in June 2008, performing "Like A Ball & Chain".

Another song from the album, "I Don't Live in a Dream", was featured on episodes of the NBC television series Life in November 2008 and ABC's Private Practice in March 2009.

Past members included Jeremy Plog, Steve Taylor, Zack Bowden, Henderson Phillips, Matt McCord, Bruce Spencer, Ben Lefever, and Nick Swimley.

In spring 2013, Greene joined the Black Crowes as lead guitarist, replacing Luther Dickinson, for the band's Lay Down With Number 13 world tour.