The Southern Harmony and Musical Companion is the second studio album by American rock band the Black Crowes, released on May 12, 1992.

It was the first album by the band to feature Marc Ford on lead guitar, replacing Jeff Cease, who was fired the year before, and the first to feature keyboardist Eddie Harsch.

The album's name derives from the full name of the Southern Harmony, an influential 1835 hymnal compiled by William Walker.

A box set featuring the remixed album along with previously unreleased songs and live tracks was released in late 2023.

In 2005, The Southern Harmony and Musical Companion was ranked number 477 in Rock Hard magazine's book The 500 Greatest Rock & Metal Albums of All Time.