[7] Joseph began her career as a featured performer and singer in the Billy Barnes Revue of 1958, with future husband and actor Ken Berry.

[8]: 640 She is also known for portraying Audrey Fulquard in the original version of The Little Shop of Horrors (1960), as well as Charlene Hensley in Hogan's Heroes (1966), Sheila Futterman in Gremlins (1984) and Gremlins 2: The New Batch (1990), Mrs Kirkland in Police Academy 2: Their First Assignment (1985) and Police Academy 4: Citizens on Patrol (1987),[citation needed] and the voice of Melody in the animated series Josie and the Pussycats and Josie and the Pussycats in Outer Space.

Joseph's other television credits include The Andy Griffith Show (Season 4 Episode 17: "My Fair Ernest T. Bass" as Ramona Ankrum), The Dick Van Dyke Show (two appearances), That Girl, F Troop (Season 1 Episode 17: "Our Hero, What's His Name" as Corporal Randolph Agarn's girlfriend Betty Lou MacDonald), Hogan's Heroes (Season 1 Episode 28: "I Look Better in Basic Black" as Charlene Hemsley), McHale's Navy, Gomer Pyle, U.S.M.C.

On November 29, 1962, their son, Joseph Larson Berry, was born but died six days later on December 5, 1962.

[13] Joseph protested in a picket line in front of Disney offices with actor Adam Arkin and his wife Michelle during the 2023 SAG-AFTRA strike.