[3] Jackson County is included in the Pascagoula, MS Metropolitan Statistical Area.

As of the 2020 United States census, there were 143,252 people, 56,323 households, and 38,007 families residing in the county.

School districts in the county include:[12] The Jackson County School District serves the Hurley, Wade, Big Point, Three Rivers, Harleston, Vestry, Latimer, and Vancleave communities, along with St. Martin and a small portion of Escatawpa.

The Pascagoula-Gautier School District serves Pascagoula and most of the City of Gautier.

Like most of the Solid South, Jackson County consistently voted for the Democratic presidential candidate through 1960, except for 1948, when it was carried by Dixiecrat Strom Thurmond.