[12] In 2016, Scott was cast to play Georgie Denbrough in the 2017 film adaptation of Stephen King's novel It.

[16][17] Continuing in the horror genre, Scott played the title role of Miles Blume in the 2019 film The Prodigy, directed by Nicholas McCarthy.

This marked his first starring role in a feature film, co-starring alongside Taylor Schilling.

[18][19] Andrés Muschietti had recruited Scott to be a part of his one-hour series pilot of Locke & Key for Hulu as one of the leading young actors opposite Frances O'Connor.

The writers of the series met Jackson while filming so they could incorporate aspects of his real-life personality into the character of Bode.

Scott also said in the same interview that he grew very close to the other actors of Locke & Key while they were filming the series.

"[27] In 2018, Scott was cast in the role of Tate Millikin for the independent film Gossamer Folds, directed by Lisa Donato.