In the fall of 1863, Mohave chief Irataba created a storm when he walked down Jackson Street, dressed in what Arthur Woodward described as "the full civilized costume" typical of European Americans, which Irataba soon preferred to traditional Mohave clothing.

[clarification needed] The section of Jackson Street between Montgomery and Sandsome Avenues is of historical interest.

In the aftermath of the earthquake, the Army decided not to demolish the buildings on this block for fear of detonating the barrels of whiskey in the warehouse, which would cause an explosion.

[citation needed] Notable buildings along the road from east to west include the Eureka Theatre, International Hotel Manilatown Center, Golden Gate Fortune Cookie Factory, the San Francisco Chinese Hospital, Han Palace Antique and Art Center, Jackson Market, the German Consulate, Jackson Court, the San Francisco Public Montessori, Calvary Presbyterian Church, Whittier Mansion and San Francisco University High School.

[6] In addition, the Academy of Art University owns and operates a building on the street for graduate apartments.