Jacksonville High School is a 5A public high school located in Jacksonville, Texas, United States.

It is part of the Jacksonville Independent School District located in north central Cherokee County.

[2] Jacksonville High School has recently undergone the first major construction since the late '50s and is now more open to accommodate for the recent switch to a 5A public high school.

The Jacksonville Indians compete in the following sports:[3] Jacksonville and rival Nacogdoches played in the longest high-school football game in history, a 12-overtime affair in 2010 which resulted in Jacksonville winning 84-81.

[4] Only four years later the two would play a (short, by comparison) five-overtime game, with Jacksonville again winning, this time 85-79.