After the 1933 general election, De Wilde was appointed as Minister of the Interior in the Colijn II cabinet, taking office on 26 May 1933.

On 19 May 1939 De Wilde resigned after disagreeing with the cabinet's decision to not implement a stronger austerity policy.

De Wilde once more returned to the House of Representatives after the resignation of Hendrik Botterweg, taking office on 19 September 1939.

On 10 May 1940 Nazi Germany invaded the Netherlands and the government fled to London to escape the German occupation.

Following the end of World War II, Queen Wilhelmina ordered a Recall of Parliament and De Wilde remained a member of the House of Representatives, taking office on 20 November 1945.