Jacoba van den Brande (Dutch pronunciation: [jaːˈkoːbaː vɑn də(m) ˈbrɑndə]; 4 July 1735 – 14 August 1794)[1] was a Dutch culture personality.

Jacoba van den Brande was born on 4 July 1735 in Middelburg in the Netherlands.

She was the daughter of Johan Pieter van den Brande (1707-1758) and Mary Heron Berg (1707-1775), both of whom came from prominent Zeeland families.

She was the founder and first chairperson of the Physics/Natural History Society of Women in Middelburg (Dutch: Natuurkundig Genootschap der Dames te Middelburg) (1785), the first all-female science academy in the world.

Van den Brande died on 14 August 1794, at the age of 59, in Middelburg.