On 10 September 1486, he married Lorenzo's daughter Lucrezia de' Medici, with whom he had ten children.

The son of Giovanni Salviati and Maddalena Gondi, he devoted himself to the economic affairs of the family, becoming very wealthy.

[1] He was granted a salt monopoly in Romagna, and became a high officer in the Vatican treasury.

[1] He tried unsuccessfully to prevent the Siege of Florence (1529–1530), and was among the advisers of Pope Clement VII during his meeting with Charles V, Holy Roman Emperor.

In 1531, he was part of the balìa of 200 Florentine citizens charged with reforming the republican government.