Jacopo Siculo, also known as Giacomo Santoro da Giuliana (1490-1544) was an Italian painter of the Renaissance, mainly active in Umbria.
He also painted a fresco altarpiece for the Spinelli Chapel in the church of Santa Maria de Loreto in Spoleto.
For the church in Brizio, outside of Spoleto, he painted an altarpied and frescoes in the presbytery (1541-2).
In Bettona, he painted a Virgin in Glory with Saints altarpiece (1547), now in the Pinacoteca Civica.
In Norcia, he painted an altarpiece for the Franciscan Convent of the Annunziata, depicting the Coronation of the Virgin (1541) and other panels, now in the city museum.