Jacqueline Gottlieb is an American neuroscientist who is a professor of neuroscience and the Principal Investigator at the Columbia University Zuckerman Institute.

She moved to Yale University for doctoral research in neurobiology, and became fascinated by the frontal cortex.

After earning her doctorate, Gottileb moved to Uniformed Services University of the Health Sciences in Maryland, where she worked on in vitro slice recordings in the barrel cortex.

[2][3] She studies the fundamental mechanisms that underpin cognitive function, such as decision making and memory.

[4] She is interested in how the brain gathers evidence during everyday tasks and when people are curious,[5] as well as disorders that reduce attention, such as depression and drug addiction.