Loussier composed film scores and a number of classical pieces, including a Mass, a ballet, and violin concertos.

[5] Loussier began composing music while studying at the Conservatoire National Musique, having moved by then to Paris, with Nat, from the age of 16.

[5] Early in his career, Loussier was an accompanist for singers Frank Alamo, Charles Aznavour, Léo Ferré and Catherine Sauvage.

[7] In 1959, he formed the Jacques Loussier Trio with string bass player Pierre Michelot—who had played with Django Reinhardt and the Quintette du Hot Club de France—and percussionist Christian Garros.

Besides Bach, the trio recorded interpretations of compositions by Handel, Scarlatti, Vivaldi, Mozart, Beethoven, Chopin,[9] Satie, Debussy, Ravel, and Schumann.

[citation needed] Loussier's last albums, My Personal Favorites[13] and Beyond Bach, Other Composers I Adore, were released in 2014 on the occasion of his 80th birthday.

[15] In March 2002, Loussier filed a $10 million lawsuit against rapper Eminem and The Marshall Mathers LP executive producer Dr. Dre, claiming that the beat for the track "Kill You" was stolen from his composition Pulsion.

These included the scores for the films Heaven on One's Head (1965), À Belles Dents (1966), The Killing Game (1967), Dark of the Sun (1968), Monique (1970) and The Man Who Went Up in Smoke (1980), the theme tune for the popular 1960s French TV series Thierry la Fronde,[11] and the original sign-on music for La 3e chaîne, the predecessor television channel to France 3.