[1] Born in Le Mans into a bourgeois family, he studied at the Collège de Navarre in Paris, where his brother Jean was a professor of mathematics and philosophy.
He subsequently studied law and medicine, frequented the literary circle around Marguerite de Navarre and from 1541 to 1543 he was secretary to René du Bellay.
In 1547 he produced a funeral oration for Henry VIII of England and published his first poems (Œuvres poétiques), which included translations from the first two cantos of Homer's Odyssey and the first book of Virgil's Georgics, twelve Petrarchian sonnets, three Horacian odes and a Martial-like epigram; this poetry collection also included the first published poems of Joachim Du Bellay and Pierre de Ronsard (Ronsard would include Jacques Pelletier into his list of revolutionary contemporary poets (La Pléiade).
In 1555 he published a manual of poetic composition, Art poétique français, a Latin oration calling for peace from King Heney II and Emperor Charles V, and a new collection of poetry, L'Amour des amours (consisting of a sonnet cycle and a series of encyclopedic poems describing meteors, planets and the heavens), which would influence that poets Guillaume du Bartas and Jean-Antoine de Baïf.
While maintaining the original system of the French mathematician Nicolas Chuquet (1484) for the names of large numbers, Jacques Pelletier promoted milliard for 1012 which had been used earlier by Budaeus.