He has worked with notable directors like Kodi Ramakrishna, S. V. Krishna Reddy, Ram Gopal Varma, Krishna Vamsi, E. V. V. Satyanarayana, Gunasekhar, Chandra Sekhar Yeleti, Siva, A. M. Rathnam, K. Raghavendra Rao, Radha Mohan, Mohan Raja, J. D. Chakravarthy, Boyapati Srinu, Trivikram Srinivas, Vysakh, K. S. Ravikumar, Sukumar and Prashanth Neel.

[5] Babu made his lead debut in Telugu with the movie Simha Swapnam (1989) which was produced by his father and directed by V. Madhusudhana Rao.

He won the Nandi Award for Best Actor in 1996 for his role in the movie Maavichiguru directed by S V Krishna Reddy.

In 2016, Babu's role as a London-based billionaire in Sukumar-directed Nannaku Prematho, starring Jr NTR, was also appreciated.

In the 2018 film Rangasthalam, also directed by Sukumar, Babu played an oppressive president of the eponymous village.

[3] His antagonist role in the Trivikram Srinivas-directed film Aravinda Sametha Veera Raghava is termed as one of finest performances of his career.

[10][3] In 2019, his notable works were Maharshi along with a crucial role in Sye Raa Narasimha Reddy.

[15] He also played the role of Rajamannar in the blockbuster film Salaar: Part 1 – Ceasefire directed by Prashanth Neel in 2023.