[1] Some of her early television appearances included minor guest roles in BBC One's Casualty, The Bill, Love Soup and ShakespeaRe-Told: The Taming of the Shrew.

[citation needed] In 2005 she played Ruth Kettering on the BBC television series Poirot (Season 10, episode 1 The Mystery of the Blue Train.)

[6] She starred in the horror film Devil's Playground (2010), directed by Mark McQueen,[7] and then appeared as Helena G. Wells on the Syfy series Warehouse 13.

[8] Murray's portrayal of Wells received critical praise and was described as "saucy",[9] "superb",[10] as able to "anchor a series"[11] and "endlessly fascinating".

[citation needed] Murray also had a guest appearance in 2009 on CBS series NCIS, playing ICE Agent Julia Foster-Yates.

Murray made an appearance on the Partially Examined Life philosophy podcast, playing a part in Sartre's No Exit, alongside Lucy Lawless, Mark Linsenmayer and Wes Alwan.