[1] Isaac is of Ojibway and British descent and is a member of Sagkeeng First Nation.

[2] She holds a master's degree from the University of British Columbia and a BA in art history with an Arts and Cultural Management Certificate from the University of Winnipeg.

[2] Her Masters of Arts thesis was titled, "Decolonizing curatorial practice: acknowledging Indigenous cultural praxis, mapping its agency, recognizing its aesthetic within contemporary Canadian art.

[5] In 2010, Isaac was employed as the visual arts coordinator for the Truth and Reconciliation Commission of Canada.

[8] In 2021, she was appointed chief curator at the Art Gallery of Greater Victoria.