In 2003, he returned to show business under GMA Network and appeared in the youth-oriented drama series, Click, where he was welcomed as a member of its third batch.

He portrayed Andrew - a rich, spoiled and irresponsible teen guy secretly in love with leading actress Roxanne Guinoo.

He portrayed David “Dave” Garcia, Jr, a jack-a-dandy soldier in the Philippine Army caught in a love triangle with Gerald Anderson and Kim Chiu.

In 2011, he joined the main cast as Edward in the Filipino remake of the Korean drama Green Rose alongside Jericho Rosales, Anne Curtis and Alessandra De Rossi.

Different from a super-powered boy with a giant bird in the comic, Darmo Adarna in the show grows up as an overweight loser who is magically transformed into a muscular hero.

In 2012, he played the role of Paul Raymundo in Kung Ako'y Iiwan Mo alongside two female stars Shaina Magdayao and Bangs Garcia, The triangle love and OFW story in the film attracted the interest of audience.

Also that same year, he was part of the primetime series Kahit Puso'y Masugatan as Rafael - a young and charming photographer with a tragic life.

In 2013, he portrayed the role of Luis Sancuevas in the Filipino remake of Maria Mercedes with leading lady Jessy Mendiola and Jason Abalos.

[6] In 2022, he appears in The Iron Heart as Eros del Rio, the main antagonist in season 2 of the series who works as a CIB Agent but he is actually a secret leader of a crime organization called Altare.

On the night of October 9, 2021, the actor's black Jeep Wrangler hit a Mandaluyong police car stationed a checkpoint along Shaw Boulevard as part of a buy-bust operation.

A plainclothes officer reported that Cuenca had not stopped for routine inspection and instead rammed through the checkpoint barriers, prompting police to chase him until his tires were shot and he was cornered along West Capitol Road in Pasig.