Directed by Malu L. Sevilla, Avel E. Sunpongco and Manny Q. Palo, it stars Kim Chiu and Coco Martin, Julia Montes, Jake Cuenca and KC Concepcion.

The entire first season followed the lives of Samuel (Coco Martin), Isabel (Kim Chiu), Mona (Julia Montes) and Franco (Jake Cuenca) encompassing the period between 1964-1984.

In the second season, the story revolved around Gabriel (Coco Martin), Andrea (Kim Chiu), and Natalia (KC Concepcion) and is set in the year 2005, with brief flashbacks from the 1990s.

Eduardo Hidalgo (Tirso Cruz III), a wealthy landowner based in Salvacion, Negros Island, has a relationship with one of the workers in his plantation, Elena Severino (Cherry Pie Picache).

Elena and Miranda give birth to their respective children named Samuel and Franco, with the latter not being Eduardo's biological son but that of a beauty contest judge.

In the era of the sugar industry boom in the small town of Salvacion, two children from opposite sides of society will meet: the young Samuel Severino (Zaijian Jaranilla) and Isabel Miravelez (Alyanna Angeles).

Samuel is the son of sugarcane plantation worker Elena, while Isabel is the daughter of wealthy couple Gonzalo (John Estrada) and Rebecca Miravelez (Angel Aquino).

Through Isabel, Samuel meets Franco Hidalgo (Louise Abuel), the son of wealthy landowners Miranda and Eduardo.

Relentless in their pursuit to know the truth as to who was behind the fire, Gonzalo and his right-hand man Pacquito (Ronnie Lazaro) was able to pinpoint a farmer as the culprit.

Meanwhile, Mona Roque (Julia Montes), the loyal friend and secret admirer of Samuel (Coco Martin), also returns to Salvacion from Manila where she studied.

In the aftermath of the explosion, a dying Elena gives Andrea to Roger (Neil Coleta) and Esther Sanggalang (Marlann Flores) who then raise her; not knowing the real identity of the little girl, they name her Jacqueline after their deceased daughter.

Elena, her parents Damian and Trinidad Severino, Gonzalo and Rebecca all perished in the ship explosion, and Gabriel is left to the care of Mona's sister Lupe Roque (Meryll Soriano) and her friend (and future husband) Calixto de la Cruz (Lester Llansang).

Days later, an old lady finds Isabel and takes care of her, while Samuel confronts Franco and is unjustly imprisoned for 20 years.

Lupe (Rio Locsin) and Calixto (Nonie Buencamino) moved to Manila along with Gabriel (Yogo Singh) and their newborn daughter Darlene, after learning that Franco had engaged in land grabbing of Samuel's properties.

Gabriel (Coco Martin) begins his revenge against him by sabotaging Natalia's (KC Concepcion) wedding to James (Bryan Santos) as he produces photos showing the latter flirting with another woman.

Isabel (Amy Austria-Ventura), introducing herself as Dolores, helps Esther (Arlene Muhlach) after the latter collapses in a public market.

She becomes friends with Esther and Roger (Smokey Manaloto), and later meets Jacq (Kim Chiu), whom she is able to recognize as her daughter Andrea.

Charges of murder, falsification of documents, and domestic violence are filed against Franco, but despite a legislative inquiry and the issuance of a warrant of arrest against him by the NBI, he refuses to surrender, holding Andrea hostage.