[3] DeBrusk went to the 2016 Memorial Cup with the host Rebels, where they were eliminated by the Rouyn-Noranda Huskies in the semi-final match.

[5] DeBrusk signed a three-year entry-level contract with Boston[6] and was assigned to the Providence Bruins for the 2016–17 season.

[7] His goalscoring ability helped lead the Bruins to the Eastern Conference Finals of the Calder Cup playoffs, where they would lose in five games to the Syracuse Crunch.

DeBrusk made an immediate impact, scoring his first NHL goal and assist in the Bruins season opener against the Nashville Predators.

The Bruins were set to play the Toronto Maple Leafs in the opening series of the 2018 Stanley Cup playoffs.

DeBrusk looked to turn on the jets as the Bruins faced off against the Columbus Blue Jackets in the second round.

Although DeBrusk did not record a point in the first two games of the series, he finished off the series strong, with a goal and two assists in the final four games, helping the Bruins advance to the Eastern Conference Finals, where DeBrusk and the Bruins would take care of the Carolina Hurricanes with ease.

Amidst the pandemic, the NHL announced that the rest of the regular season was cancelled, and that postseason play would start up in July 2020 in a bubble.

However, the Bruins would fail to avenge their loss in the Final the previous season, as they fell in five games to the Lightning the following round.

[17] Amidst the hot scoring streak, and playing with Bruins stars Patrice Bergeron and Brad Marchand, questions were raised whether DeBrusk had a change of heart about his trade request earlier in the season.

[18] On March 21, 2022, the day of the 2022 NHL Trade deadline, DeBrusk signed a two-year, $8 million extension with the Bruins.

During the 2023 NHL Winter Classic, DeBrusk scored both goals in a 2-1 victory at Fenway Park over the Pittsburgh Penguins.

[22] It wouldn't be until February 18 that DeBrusk would return, and in his comeback, he scored a goal and an assist in a 6-2 victory over the New York Islanders.

[24] In the month of March, DeBrusk scored five goals and seven assists in 14 games, helping the Bruins in their push to repeating as Atlantic Division champions.

Unfortunately, a slow end for DeBrusk and the Bruins had them missing out on the title by one point to the Panthers, and once again setting up a matchup with the Maple Leafs in round one of the playoffs.

On July 1, 2024, after seven seasons with the Bruins, DeBrusk signed a seven-year, $38.5 million contract with the Vancouver Canucks.