In his youth, Eisenscher was associated with a group of Jewish intellectuals that included Itsik Manger, Eliezer Steinbarg, Bernard Reder and others.
Influenced by German Expressionism, Eisenscher eventually began creating portraits and figurative paintings.
His paintings also included visions of the Jewish "shtetls" in Eastern Europe, markets, synagogues and scenes of Israel and its people.
His series "Gate" (1969) received much attention as well as the painting "The Night of the 29th of November" which is part of the Knesset collection.
A collection of the artist's portrait photographs and letters from the Eisenscher estate is found today at the Information Center for Israeli Art in the Israel Museum, Jerusalem.