He was also the Reichsstatthalter (Reich Governor) and Minister-President of the People's State of Hesse, the Oberpräsident of the Prussian Province of Nassau and an SA-Obergruppenführer.

He attended volksschule there and after graduating from the gymnasium in Bad Bergzabern in 1901, he served as a one-year volunteer with the 18th Royal Bavarian Infantry Regiment “Prince Ludwig Ferdinand,” headquartered in Landau.

He subsequently served as a deputy company commander and a poison gas defense officer (gasschutzoffizier) in Pinsk and Rivne in Ukraine.

In June of that year, he gravitated to the National Socialist Freedom Party, another Nazi front group, and was put on its executive board.

In January 1930 he became the Nazi faction leader in both bodies and, in addition, was made a member of the Prussian State Council.

In April 1931, Sprenger became the Reich Specialist for Civil Service Questions in the Party Reichsleitung (National Leadership).

In the process of the Gleichschaltung, in particular due to the Reichsstatthaltergesetz (Reich Governors Law) of 30 January 1935, he was also appointed Minister-President and took over leadership of the state government from Philipp Wilhelm Jung on 1 March 1935.

[8] From that time forward, Jews were rounded up and deported by train from Frankfurt to ghettos and extermination camps in the east.

[9] When the Second World War broke out on 1 September 1939, Sprenger was named Reich Defense Commissioner for Wehrkreis (Military District) XII, based in Wiesbaden.

In 1943, the Oberpräsident (High President) of the Prussian Province of Hesse-Nassau, Philipp von Hessen, fell out of favor and was removed from office.

[10] On 15 March 1945, with U.S. Army forces already across the Rhine river, Sprenger issued orders to his Kreisleiters on the need to keep the German population “in check” by having the Gestapo arrest “rumor mongers” and send them to concentration camps.

He also ordered the destruction of secret documents relating to concentration camps and the “extermination of some families.” The memo also stated: Germans who do not defend themselves on the approach of the enemy or who wish to flee, are to be shot down ruthlessly, or, where suitable, hanged to frighten the population.

[11]As American armed forces approached Frankfurt, Sprenger issued further orders on 23 March 1945 prohibiting any able-bodied man or woman from leaving the city.