He played college football for the Michigan Wolverines, and was selected by the Atlanta Falcons in the third round of the 2021 NFL draft.

Mayfield grew up in Grand Rapids, Michigan, and attended Catholic Central High School, where he was a four year starter at offensive tackle and defensive end for the football team.

[8][9] Following the 2020 season, Mayfield announced that he would forgo his remaining years of college eligibility and enter the 2021 NFL draft.

[15] Heading into his first NFL training camp, Mayfield competed with Kaleb McGary to be the Falcons' starting right tackle.

At the conclusion of the NFL preseason, Mayfield was named the starting left guard for the Falcons.