He played college football for the Florida Gators, where he was named a unanimous All-American and won the John Mackey Award in 2020.

[3][4] Sources: Pitts played in 11 games as a backup his true freshman season at Florida in 2018.

[6][7][8] During the 2020 season, curtailed by the COVID-19 pandemic, Pitts scored 12 touchdowns in eight games while gaining 770 yards on 43 receptions.

[9] He was named a unanimous All-American and won the John Mackey Award as the most outstanding tight end in college football for the season.

[17] In Week 5 against the New York Jets at Tottenham Hotspur Stadium, Pitts caught nine passes for 119 yards and his first NFL touchdown in the 27–20 win.

[20] In that game, Pitts surpassed Tony Gonzalez for the Falcon franchise record for the most receiving yards in a single season by a tight end.

[21] In Week 17 against the Buffalo Bills, Pitts joined Hall of Famer Mike Ditka as the only rookie tight ends in NFL history to surpass 1,000 receiving yards.

[31] On November 30, 2022, Pitts was ruled out for the remainder of the season after having surgery to repair the MCL in his right knee.