He spent time playing for the St. Louis Blues, Toronto Maple Leafs, Calgary Flames, San Jose Sharks and won the Stanley Cup with the Chicago Blackhawks in 2013.

On January 31, 2010, Mayers was traded along with Matt Stajan, Niklas Hagman and Ian White to the Calgary Flames for Dion Phaneuf, Fredrik Sjöström and prospect Keith Aulie.

[6][7] On April 5, 2012, late in the 2011–12 season, Mayers was headbutted by the Minnesota Wild's Nate Prosser during a scrum in front of the net.

[10] Mayers was a member of the Canadian 2007 IIHF World Championship team that won gold in a 4–2 win against Finland in Moscow.

[11] He was also a member of the Canadian 2008 IIHF World Championship team, helping Canada take home the silver medal.