Practicing in Gulf Breeze, Florida, Andrews has become one of the best-known and most popular orthopedic surgeons and has performed on many high-profile athletes.

Andrews received his undergraduate and medical degrees from Louisiana State University, where he was an athlete, winning a Southeastern Conference Championship in polevaulting.

[7] In November 2018, retired defensive tackle Sharrif Floyd filed a $180 million medical malpractice lawsuit against Andrews for causing him debilitating muscle and nerve damage after performing an unpermitted knee surgery on him in September 2016.

[10] Andrews provided a second opinion to team doctors, performed a successful surgery on a torn labrum, and Clemens made a full recovery.

Andrews would gain a reputation as an "athlete-centric" doctor, operating on athletes including Drew Brees, Bo Jackson, Michael Jordan, Jack Nicklaus, John Smoltz, Triple H, Brett Favre, Chris Godwin, Chase Young, Marcus Lattimore, and Adrian Peterson.