He played college football for the Penn State Nittany Lions and was selected by the Buccaneers in the third round of the 2017 NFL draft.

[3] He played high school football for the Cavaliers and was a key member responsible for a 41–7 record over his four years and two State Championships.

[5] Sources: In Godwin's freshman year, he appeared in all thirteen games for the Nittany Lions, recording 338 yards on 26 receptions.

After struggling to find his stride at the start of his junior season, Godwin finished with 117 yards receiving and a touchdown against the Temple Owls.

[9] In what proved to be his final game as a Nittany Lion, Godwin recorded a career-high 187 yards on nine catches and scored two touchdowns in a Rose Bowl loss to USC.

[11] On January 5, 2017, Godwin announced via his Twitter that he decided to enter the 2017 NFL draft, forgoing his final year of eligibility at Penn State.

[15] In March 2017, Godwin performed well at the 2017 NFL Combine, having one of the top vertical jumps and 40-yard dash time among wide receivers.

[16] Due to his success at the combine, he was interviewed there by multiple teams including the Philadelphia Eagles, Chicago Bears, Tampa Bay Buccaneers and San Francisco 49ers, among others.

[20][21] In the regular season finale against the New Orleans Saints, Godwin caught nine passes for 111 yards and a touchdown as the Buccaneers won 31–24, earning him National Football Conference (NFC) Offensive Player of the Week.

[37] In Week 15, during a 38–17 win against the Lions, Godwin caught five passes for 121 yards but injured his hamstring during the third quarter and left the game.

[43] During the season-opener against the Saints, Godwin recorded six receptions for 79 yards but suffered a concussion from a hit by safety D. J. Swearinger which forced him to exit the eventual 34–23 road loss and miss the following week.

[44][45] Godwin returned in Week 3 against the Denver Broncos, in which he recorded five receptions for 64 yards and a touchdown, his first from new Buccaneers quarterback Tom Brady.

[48] During Week 12, Godwin hauled in 8 of 9 targets for 97 yards as the Buccaneers narrowly lost, 27–24, to their eventual Super Bowl opponent, the Kansas City Chiefs.

[59][60] During the season-opening 31–29 victory over the Dallas Cowboys, Godwin recorded nine catches for 105 yards and a touchdown, including a critical 24-yard reception on Tampa's final offensive possession to put them within range for kicker Ryan Succop to kick a game-winning 36-yard field goal.

[66] During a Week 13 30–17 road victory over the Falcons, Godwin recorded a career-best and franchise record-setting 15 receptions for 143 yards as well as a nine-yard carry.

[67] On December 19, 2021, Godwin tore his ACL and sprained his MCL in the Buccaneers' Week 15 9–0 shutout loss against the Saints, prematurely ending his season.

[79] In Week 7 against the Baltimore Ravens, Godwin had suffered a left ankle injury late in the 4th quarter, requiring him to be carted off the field.