He was born in the Waxhaw settlement, Lancaster County, South Carolina to Sarah Douglass and William Blair, immigrants from Ireland.
He was elected as a Jacksonian to the Twenty-first through Twenty-third Congresses and served from March 4, 1829, until his death in Washington, D.C., on April 1, 1834.
[4] Adams subsequently characterized Blair as "... an honest and very intelligent man ruined by the habits of intemperance and maddended with opium.
"[5] Under date of April 2, 1834, Adams records in his diary that Blair "shot himself last evening at his lodgings ... after reading part of an affectionate letter from his wife, to Governor Murphy, of Alabama who was alone in the chamber with him, and a fellow-lodger at the same house.
"[6] He was buried in Congressional Cemetery; his tombstone inscription includes his command as General of the South Carolina 5th Militia Brigade.