[2] Blake departed A&M in favour of sister label Republic Records, on which he released his second album, Overgrown (2013) to further critical and commercial success; it likewise peaked within the chart's top ten and moderately entered the US Billboard 200.

Often doing so with Oneohtrix Point Never, Dominic Maker, Justin Vernon or his partner Jameela Jamil, Blake has been credited on releases for Jay-Z, Kanye West, Beyoncé, Kendrick Lamar, Frank Ocean, Rosalía, Strick, JID, Travis Scott, Normani, and Lil Yachty.

[8] While at university, Blake and friends hosted a series of "Bass Society" music nights that featured UK artists such as Distance, Skream and Benga.

Having been released on the record label Hemlock, the extended play became a favourite of BBC Radio 1 DJ Gilles Peterson.

[9] Soon after the release of the record, Blake was invited by Peterson to do a special mix on his international show, including an exclusive Mount Kimbie track.

[11] The title track, "CMYK" was selected by BBC Radio 1 DJ Nick Grimshaw as his Record of the Week[12] and also received airplay from other DJs.

On 29 September 2010, Zane Lowe selected Blake's cover version of "Limit to Your Love" as his "Hottest Record in the World".

These EPs, noticeably more structured than his previous releases, featured R&B-tinged work as opposed to the experimental electronic style found on CMYK.

Also in 2012, Blake and friends (including Foat, Nick Sigsworth, and touring musicians Rob McAndrews and Ben Assiter) secured a residency at the club Plastic People as the collective 1-800 Dinosaur, hosting a series of impromptu dance nights.

[28] The album features guest appearances from noted electronic music producer Brian Eno and rapper RZA of Wu-Tang Clan.

Blake revealed to Hot Press that falling in love had influenced the warm nu-soul sound on the album, as opposed to the experimentalism found on his self-titled effort.

[30] A remix featuring Chance the Rapper, of a track from Overgrown, "Life Round Here", was released on 11 October alongside a music video directed by Nabil Elderkin.

[47] In December 2017, Blake released a cover of the song "Vincent" by Don McLean alongside a performance video shot in the studio.

[49] On 26 January 2018, Blake released a new single, "If the Car Beside You Moves Ahead", alongside its music video, having premiered at his BBC Radio 1 residency.

[53] Blake's second solo single of that year, "Don't Miss It", was shared on 24 May alongside a lyric video and was released the next month.

"[56][57] Blake mixed and worked on additional production on the ninth album by American electronic musician Oneohtrix Point Never, titled Age Of, which was released in June 2018.

[58] He also co-wrote and was featured on the track "Stop Trying to Be God" from Travis Scott's third studio album, Astroworld, and made an appearance in the song's music video.

A mostly stylistically traditional release, the record was followed-up by an ambient album titled Wind Down on 18 March 2022, created with German artificial intelligence media company Endel to help listeners fall asleep.

[86] On 28 July 2023, Blake was featured alongside 21 Savage on the track "Til Further Notice" from Travis Scott's fourth studio album, Utopia.

[95][96][97] On releases such as The Bells Sketch, CMYK and Klavierwerke, Blake's own voice is obscured and processed, also incorporating vocal samples from '90s R&B, prominent sub-bass frequencies, and uneven, sparse rhythms.

[100][101] By the time of his 2011 debut album, Blake's vocals and piano had become more prominent while traditional song structures became increasingly apparent, reflecting the influence of gospel and soul.

"[95] Dash Lewis of Pitchfork summarized his career as a "journey from club deconstructionist to pop auteur," describing his 2021 album Friends That Break Your Heart as a "brightly colored, features-heavy singer-songwriter collection that careened through genres, light-years from the minimalism of his early work.

[103] Blake was formatively influenced by the sparse dubstep of Burial and Digital Mystikz alongside singer-songwriters such as Stevie Wonder, D'Angelo, Joni Mitchell, and Sly Stone.