Referencing architecture, art history, and film, Casebere’s abandoned spaces are made from tabletop constructions of simple materials pared down to essential forms.

In the early 1990s, Casebere turned his attention to the development of different cultural institutions during The Enlightenment, and their representation as architectural types, particularly prisons.

Casebere's photographs of sculptural installations suggest "an element of unreality that sparks a feeling or causes viewers to question the space and fill it with answers of their own".

His work also references modern architects like Victor Horta (Spiral Staircase, and Turning Hallway) and Richard Neutra (Garage, and Dorm Room).

His first works in this period were inspired by the 10th century Andalusia because of the co-operation between Islamic, Jewish, and Christian cultures preceding the Inquisition (La Alberca, Abadia, Spanish Bath, Mahgreb).

The Centre for Fine Arts, Brussels ("Bozar") displayed After Scale Model: Dwelling in the Work of James Casebere[6] in 2016.

Casebere's newest body of work, Emotional Architecture,[7] debuted at Sean Kelly Gallery in 2017, and was then exhibited at Galería Helga de Alvear in 2017–2018[8] and at Galerie Templon in Brussels.