He played college football for the Georgia Bulldogs and was selected by the Bills in the second round of the 2022 NFL draft.

[15] He was the leading receiver for Georgia with 112 yards and one touchdown on four receptions in the team's 34–11 win over Michigan in the Orange Bowl semifinal game.

[25] Cook scored a rushing touchdown in the Wild Card Round 34–31 victory over the Miami Dolphins.

[26] Cook became Buffalo's primary running back for the 2023 season with previous starter Devin Singletary departing for the Houston Texans in free agency,[27] though goal-line and pass protection snaps went to veteran signing Latavius Murray.

Against the Dallas Cowboys in week 15, Cook attained career highs in several single-game categories, including rush attempts (25), rush yards (179), total scrimmage yards (221), and total touchdowns (2), as the Bills routed Dallas 31–10.

[28] The following week against the Los Angeles Chargers, Cook surpassed 1,000 rushing yards on the season, becoming the first Bills running back to do so since LeSean McCoy in 2017.

On the season, he finished tied with Derrick Henry and Jahmyr Gibbs as the NFL rushing touchdowns leader with 16.

Athens-Clark County deputy solicitor Janna Landreth offered to drop additional charges in the case if Cook pleaded guilty to reckless driving, for which Cook would have to pay a $670 fine, supply financial restitution to at-most two of the five damaged vehicles, and complete a defensive-driving course.

Cook subsequently failed to appear in court relating to this case, for which Georgia Bulldogs football Director of Player Support Bryant Gantt claimed responsibility.