James David Santini (August 13, 1937 – September 22, 2015) was an American attorney, politician and lobbyist who served as the U.S. representative for Nevada's at-large congressional district from 1975 to 1983.

Santini ran for United States Senate in 1982, but was narrowly defeated in the Democratic primary by incumbent Howard Cannon.

He was succeeded by Democrat Harry Reid and Republican Barbara Vucanovich in the newly created 1st and 2nd Congressional Districts respectively.

After leaving public office, Santini remained in Washington, D.C., and worked as a lobbyist, representing a number of tourism-related corporations.

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