James Fiennes, 2nd Viscount Saye and Sele (c. 1602 – 15 March 1674) was an English peer and MP at various times between 1625 and 1660, when he succeeded his father and entered the House of Lords.

His siblings included Nathaniel (1608–1669), Bridget, John (1612–1708), Constance and Elizabeth.

[1] In the absence of a direct male heir, his nephew William (1639–1698), son of his younger brother Nathaniel, became the third Viscount Saye and Sele on his death in 1674.

He was elected MP for Oxfordshire in 1626 and in 1628 and sat until 1629 when King Charles decided to rule without parliament for eleven years.

He was re-elected MP for Oxfordshire in November 1640 for the Long Parliament and sat until 1648.