Major General Thomas Twisleton, 13th Baron Saye and Sele (c. 1735 – 1 July 1788) was a British Army officer and peer.

Twisleton was the son of John Twistleton (died 1763) of Broughton Castle, Oxfordshire, and his wife Anne Gardner.

In 1780, he oversaw the defence of the Bank of England during the Gordon Riots and was responsible for helping to restore order in London.

[3] In 1781 Twisleton successfully established his claim to the Saye and Sele Barony, and assumed his seat in the House of Lords on 29 June that year.

[2] As Lord Saye and Sele, he became colonel of the 9th (East Norfolk) Regiment of Foot in 1782 and served in that position until his early death in 1788.