James Gunn (March 13, 1753 – July 30, 1801) was a delegate to the Continental Congress and a United States Senator from Georgia.

In his first term as senator, between mid-May and late June 1789, Gunn moved from opposing the establishment of excise taxes to supporting them.

He also opposed giving the president the power to remove heads of cabinet departments without the advice and consent of the Senate.

[7] Gunn's rivalry with James Jackson, which had originated in Georgia in the period between the end of the Revolution and the launching of the new federal government, heated up in the early 1790s.

Jackson resigned from the Senate and returned to Georgia to work against Gunn, who fell in public opinion due to the Yazoo land fraud.