James Guyon Jr. (December 24, 1778 – March 9, 1846 Staten Island) was an American politician from New York.
In the United States House of Representatives elections in New York, 1818, Guyon Jr. received a larger number of votes, but Ebenezer Sage was declared elected because part of the vote was returned for "James Guyon" (omitting "Jr.").
He was seated on January 14, 1820, in the 16th United States Congress, and held office until March 3, 1821.
His half-brother Harmanus "Harry" Guyon also served in the New York State Assembly (1819–1820).
The family's local legacy includes James's nearby Guyon Tavern (c. 1820), and the landmarked Guyon-Lake-Tysen House (c. 1740), and the original Guyon-Clarke House (c. 1670) that stood until 1925 at the foot of today's Guyon Avenue.