He has been in movies and guest-starred on television shows including Frasier, Matlock, NYPD Blue, Star Trek: Deep Space Nine, and JAG.

In addition to acting, Harper has contributed his voice to several video games, most notably StarCraft as Arcturus Mengsk, Resistance: Fall of Man, and Diablo II.

Harper portrayed Louisiana State Senator Willie Rainach in the 1989 film Blaze, with Paul Newman as Governor Earl Long.

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