James Henry Robert Innes-Ker, 6th Duke of Roxburghe, KT (12 July 1816 – 23 April 1879) was a Scottish peer.

Innes-Ker was the only surviving child of the 5th Duke of Roxburghe and the former Harriet Charlewood (c. 1778–1855).

After his father's death in 1823, his mother remarried to Lt. Col. Walter Frederick O'Reilly CB of the Royal African Corps on 14 November 1827.

[1] His maternal grandfather was Benjamin Charlewood of Windlesham in Surrey and his paternal grandparents were Sir Henry Innes, 5th Baronet and Anne (née Grant) Innes.

[3] Together, James and Susanna were the parents of four children:[1] Roxburghe died in Genoa on 23 April 1879.