[4] Weeks after starring in the play, in November 1940, Anderson signed a contract with Warner Bros.[3] He made more than 120 appearances, mostly in television and several films between 1941 and 1969.

He made three guest appearances on Perry Mason, including the role of murder victim Frank Anderson in the 1958 episode, "The Case of the Pint-Sized Client," and murder victim Stanley Piper in the 1960 episode, "The Case of the Ill-Fated Faker."

He appeared in a number of westerns throughout his career, often playing a gun-for-hire or outlaw...including "Sanctuary at Crystal Springs", the controversial 1963 episode of the ABC/Warner Brothers western series The Dakotas, that led to the series' cancellation, where he played the main antagonist.

That same year he guest starred on Alfred Hitchcock Presents in the 1963 episode “Last Seen Wearing Blue Jeans” (S1E28).

[5][6] In 2010, Mary Badham, who starred alongside Anderson in To Kill a Mockingbird, praised his method acting style: "[W]hen he walked on the set, he was that character.