James Leslie (c.1610–1678) was a Scottish physician who was principal of Marischal College (now part of Aberdeen University) from 1661 to 1678.
He was born in Aberdeen the son of Thomas Leslie a burgess.
He studied medicine at Aberdeen University[contradictory] and qualified as a physician.
In 1661 he replaced William Moir as principal of Marischal College.
His position as principal was filled by Robert Paterson.