James Lewis (born 1601) was a Welsh politician who sat in the House of Commons at various times between 1624 and 1656.
He was re-elected MP for Cardiganshire in 1625, 1626 and 1628 and sat until 1629 when King Charles decided to rule without parliament for eleven years.
[2] He was a Royalist at the beginning of the Civil War, but in January 1645 was appointed one of the sequestration committee for Cardigan, Pembroke and Carmarthen Counties.
Information was laid against him on 12 February 1649 that he had fought originally for the king, had protected Royalists when on the sequestration committee and his regiment had cost the state £50,000.
He was described as "a person of inoffensive, facile constitution, forced from a Royalist to act as a colonel for King and Parliament: seldom out of publique offices, though averse to undertake any; loved more for doing no wrong, than for doing of any good".