Vice Admiral James Littleton (1668–1723) was a Royal Navy officer who served as Commander-in-Chief of the Jamaica Station.

Littleton was promoted to post captain on 27 February 1693 on appointment to the command of the sixth-rate HMS Swift Prize.

[1] Promoted to commodore, Littleton became Commander-in-Chief of the Jamaica Station with his broad pennant in the third-rate HMS Defiance, in 1710.

[3] He secured the capture of the San Joaquin in August 1711 during the War of the Spanish Succession.

[2] He went on to be Commander-in-Chief at Chatham in 1714 and, having been promoted to rear admiral on 1 February 1717, second-in-command in the Baltic Sea that year.