[3][8][9] He returned to South Australia and became an eye surgeon, working in private practice and as a visiting consultant at the Royal Adelaide and Women's and Children's Hospitals.
[10] In 2008, this evolved into Sight For All, a social impact organisation dedicated to fighting the causes of blindness[1] with projects in Aboriginal and mainstream Australian communities,[11] as well as training and equipping eye surgeons throughout Africa and Asia.
[12] He advocated for TV commercials for unhealthy products to be limited to certain hours, and asks supermarket chains to curb their "predatory sales and marketing tactics", without success.
[15] In late November 2020, he gave a controversial speech to the National Press Club outlining what he described as the country's "flawed, biased and unscientific" Australian Dietary Guidelines.
[23][24] On 20 January 2022, the Premier of South Australia, Steven Marshall, announced that Muecke would be the state's new Lieutenant Governor, succeeding Brenda Wilson.
[8][5] He is a keen amateur photographer and has held exhibitions and self-published a coffee table book, which helped fund a children's eye unit in Myanmar.