Nitties took part on the Golf Channel's series The Big Break: Mesquite where he was eliminated during the 7th episode.

Nitties qualified for the PGA Tour in 2009 by finishing in a tie for second at Q-school with Derek Fathauer, behind Harrison Frazar.

He had success in his rookie season on the PGA Tour in 2009, with two top ten finishes early at the FBR Open, where he held the first round lead and the Mayakoba Golf Classic at Riviera Maya-Cancun.

On 8 February 2019, Nitties matched the world record of nine consecutive birdies in the ISPS Handa Vic Open.

His birdie run from the 15th to the fifth in the first round set a European Tour record and matched Mark Calcavecchia's feat in the 2009 Canadian Open.