She made one voyage for the British East India Company (EIC), and two transporting convicts to New South Wales.

[3] First convict voyage (1829–1830): Under the command of Joseph Grote and surgeon James Gilchrist, she sailed from Dublin, Ireland on 2 October 1829, and arrived at Port Jackson, Australia on 20 January 1830.

[5] James Pattison sailed from Port Jackson on 13 March 1830, with passengers and cargo for Madras and Bengal, via Hobart Town.

During the voyage, James Pattison at one point became becalmed and it was necessary for her to sail round Van Dieman's Land rather than through the Bass Straight.

[10] James Pattison sailed from Gravesend on 8 November 1839 and arrived at Port Jackson in February 1840 with 187 immigrants.